Extended Data Fig. 8: SPRINTER enables the identification of clone-specific ART supported by underlying read counts.
From: Characterizing the evolutionary dynamics of cancer proliferation in single-cell clones with SPRINTER
SPRINTER identifies different ART events affecting different genes (annotated text) and present in distinct clones (a–e) that belong to different phylogenetic branches (left and right indicated by lilac and light blue rectangles) or different metastatic clades (colored triangles). SPRINTER identifies clone-specific late-to-early (dark magenta) and early-to-late (dark green) ART events in genomic regions across chromosomes (x axis) if they have calculated values of the replication timing profile per clone (clone-specific RTP, y axis) that are higher or lower, respectively, than expected.
