Extended Data Fig. 4: Convergent promoter TSSs display a positive correlation.
The expression dynamics (Log2FC Nutlin-3a compared to DMSO control) between the divergent TSSs (a) #1 and #2 as well as (c) #3 and #4 and the (b) convergent TSSs #2 and #3. (a-c) Schematics (top panel) highlight the TSSs that have been compared for their log2FC correlation (bottom panel). (d) The convergent TSSs #2 and #3 have been separated into three groups based on the basemean expression of host gene expression (elicited by TSS#2). (e) The convergent TSSs #2 and #3 have been separated into three groups based on the distance between TSS#2 and #3. (a-e) Data from RPE-1 cells. Linear regression with 95% confidence intervals. Spearman correlation with two-tailed significance.
