Fig. 6: Estimated differentiation paths from ASPCs to adipocytes in hSAT and hVAT. | Nature Genetics

Fig. 6: Estimated differentiation paths from ASPCs to adipocytes in hSAT and hVAT.

From: Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns

Fig. 6

a, The expression of the ASPC marker PDGFRA in UMAP representations of hSAT snRNA-seq atlases. ASPCs constitute a well-defined cluster. b, The proportion of ASPC subclusters within the hSAT ASPCs. c, The expression of ASPC markers and of stem, fibrosis and adipogenic markers in hSAT ASPC subclusters. d, ASPCs, classical and nonclassical adipocytes in hSAT colored by cell group (left) with inset showing ASPCs colored by subcluster. Right, nuclei colored by their differentiation pseudotime from ASPCs (ASPC1). Nonclassical adipocytes were an intermediate state between ASPCs and classical adipocytes. Visualization was performed using ForceAtlas2 (FA) representation. e,f, Same as a (e) and b (f) for hVAT. g, The expression of ASPC markers and stem, fibrosis, adipogenic and mesothelial markers in hVAT ASPC subclusters. h, Same as d for hVAT. Nonclassical adipocytes appear as an intermediate state between ASPCs and classical adipocytes. ASPC4 shows a pseudotime comparable to nonclassical adipocytes, suggesting that it might lead to a different end-state.

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