Fig. 3: Colocalization analysis for brain phenotypes using cell-type eQTLs. | Nature Genetics

Fig. 3: Colocalization analysis for brain phenotypes using cell-type eQTLs.

From: Cell state-dependent allelic effects and contextual Mendelian randomization analysis for human brain phenotypes

Fig. 3

a, Summary of colocalizations (PP.H4 > 0.8) per cell type and trait. Each bar chart is colored by cell type. Y axes indicate the number of colocalizations in that cell type. Asterisks indicate the cell type with most colocalizations with a particular trait. b, Number of unique colocalized (PP.H4) genes from single-cell-type and ‘pseudobulk’ eQTL data. c, Single cell-type colocalizations (PP.H4 > 0.8) for AD (genes on x axis and cell types on y axis). d, Colocalization Manhattan plots for the association of JAZF1 expression in microglia and AD risk. Each point represents the −log10(P) for an SNP and its association with gene expression (top) and disease risk (bottom). e, Colocalization Manhattan plots for the association of EGFR expression in astrocytes and AD risk. ADHD, attention deficit hyperactivity disorder; ALS, amyotrophic lateral sclerosis; AN, anorexia nervosa; AUDIT, alcohol use disorder; INT, intelligence; SCZ, schizophrenia; BIP, bipolar disorder; HL, hearing loss; CBV, cerebellar volume; CSA, cortical surface area; FTD, frontotemporal dementia (behavioral variant); HV L/R, hippocampal volume (left/right); ICV, intracranial volume; INS, insomnia; LAN, reading and language skills; LBD, Lewy body dementia; MCP, multisite chronic pain; MDD, major depressive disorder; NDD, neurodegenerative disease; NEUR, neuroticism; PVS, perivascular space burden; RLS, restless legs syndrome; SCV, subcortical volume; SD, sleep duration; STR, stroke; THV, whole thalamus volume; chr, chromosome.

Back to article page