Extended Data Fig. 7: Power calculations for sub-threshold cardiomyopathy genes. | Nature Genetics

Extended Data Fig. 7: Power calculations for sub-threshold cardiomyopathy genes.

From: Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Extended Data Fig. 7

This plot shows the estimated power (y-axis) at different numbers of atrial fibrillation (AF) cases (x-axis) for a range of well-known cardiomyopathy genes that reached two-sided P < 0.05 (unadjusted for multiple-testing) in our gene-based analysis of LOF and pDM variants. We assumed these genes represent true AF genes with as yet limited power; we further assumed a 1:3 case:control setting. We used the odds ratio (OR) estimates (computed from inverse-variance-weighted meta-analysis of Firth’s regression results) and the estimated cumulative minor allele frequencies (cMAF; computed among controls) as input for these calculations. The legend shows the gene names and corresponding OR estimates and control cMAF estimates from our data; each gene is annotated with a different color.

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