Extended Data Fig. 1: Forest plots for novel associations from gene-based analyses of loss-of-function and predicted-deleterious missense variants. | Nature Genetics

Extended Data Fig. 1: Forest plots for novel associations from gene-based analyses of loss-of-function and predicted-deleterious missense variants.

From: Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Extended Data Fig. 1

This forest plot shows the contributions of each cohort and the meta-analysis results for gene-based analysis of TTN, MYBPC3, LMNA, PKP2, and KDM5B; center measures show odds ratios, while error bars represent 95% confidence intervals. The odds ratio and 95% confidence interval of each study were estimated from Firth’s logistic regression and the meta-analysis odds ratios and confidence intervals were estimated from an inverse-variance weighted fixed effect approach. The P-values of the meta-analysis were computed from a score-based meta-analysis approach; P-values are two-sided and unadjusted for multiple-testing. For TTN, all datasets contributed (52,416 cases and 267,772 controls); for the other genes, TOPMed-CCDG, CCDG-WES and UKBB contributed (51,019 cases and 253,267 controls). The cMAC shows the cumulative number of alternative alleles observed in the meta-analysis. cMAC, cumulative minor allele count; Combined, meta-analysis results.

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