Fig. 3: PROX1 is necessary during liver regeneration. | Nature Genetics

Fig. 3: PROX1 is necessary during liver regeneration.

From: Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis

Fig. 3: PROX1 is necessary during liver regeneration.

a, Schematic representation of DDC diet-induced liver injury and regeneration in mice. The figure is created with BioRender.com. b, Pseudotime-ordered RNA expression of Prox1 and hepatocyte signature of mice treated as in a, across 1,866 single cells35. c, Liver injury and recovery as in a following Cre-mediated Prox1 deletion in conditional Prox1fl/fl knockout mice. d, Number of HNF4+ cells per area in livers from mice treated as in c (n = 3). e, Serum levels of ALP from mice treated as in c (n = 3). Bar graphs show mean (n = 3), error bars = s.d., and unpaired two-tailed t test. P values are displayed.

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