Extended Data Fig. 7: Risk estimates of a novel common clonal haematopoiesis (CH) risk variant identified from ASXL1-CH genome-wide association study (GWAS) in Mexico City Prospective Study (MCPS). | Nature Genetics

Extended Data Fig. 7: Risk estimates of a novel common clonal haematopoiesis (CH) risk variant identified from ASXL1-CH genome-wide association study (GWAS) in Mexico City Prospective Study (MCPS).

From: Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis

Extended Data Fig. 7: Risk estimates of a novel common clonal haematopoiesis (CH) risk variant identified from ASXL1-CH genome-wide association study (GWAS) in Mexico City Prospective Study (MCPS).

rs2958593 identified as genome-wide significant. Overall CH and gene-specific CH risk estimates conferred by the minor allele (T) shown here for 406,826 UK Biobank (UKB) and 136,401 MCPS participants. Odds ratios and unadjusted two-sided P-values were derived from Firth logistic regression implemented by REGENIE software. Measures of centre represent the odds ratio, and the error bars represent the lower and upper bound of the 95% confidence interval of the odds ratios. Full circles represent significant associations (P < 0.05) while hollow circles represent non-significant associations (P ≥ 0.05). CH, clonal haematopoiesis; GWAS, genome-wide association study; MCPS, Mexico City Prospective Study; OR, odds ratio; UKB, UK Biobank.

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