Extended Data Fig. 10: Rare CHEK2 variant burden association meta-analysis across Mexico City Prospective Study (MCPS) and UK Biobank (UKB). | Nature Genetics

Extended Data Fig. 10: Rare CHEK2 variant burden association meta-analysis across Mexico City Prospective Study (MCPS) and UK Biobank (UKB).

From: Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis

Extended Data Fig. 10: Rare CHEK2 variant burden association meta-analysis across Mexico City Prospective Study (MCPS) and UK Biobank (UKB).The alt text for this image may have been generated using AI.

a, b, CHEK2 “flexdmg” qualifying variant model identified as genome-wide significant (P value < 1 × 10−8) in overall clonal haematopoisis (CH) and DNMT3A-CH. c, d, CHEK2 “flexnonsynmtr” qualifying variant model identified as genome-wide significant in overall CH. e, f, CHEK2 “ptv5pcnt” qualifying variant model identified as genome-wide significant in overall CH and DNMT3A-CH. For each qualifying variant model, the risk estimates conferred (a, c, e) and individual variant as a percentage all CHEK2 variants identified in MCPS and UKB (b, d, f) shown. Odds ratio and unadjusted two-sided P values were derived from Cochran-Mantel-Haenszel (CMH) test. Measures of centre represent the odds ratios, and the error bars represent the lower and upper bound of the 95% confidence interval of the odds ratios. Full circles represent significant associations (P < 0.05) while hollow circles represent non-significant associations (P ≥ 0.05) (a, c,e). In total, 136,398 MCPS and 416,115 UKB participants were included for analysis here. 95% CI, 95% confidence interval; CH, clonal haematopoiesis; FHA, forkhead-associated domain; KD, kinase domain; MCPS, Mexico City Prospective Study; OR, odds ratio; SCD, SQ/TQ cluster domain (SCD); UKB, UK Biobank.

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