Extended Data Fig. 2: Frequency of clonal haematopoiesis (CH) by age.

Frequency of CH individuals by age stratified by gene-specific CH in UK Biobank (UKB; a) and Mexico City Prospective Study (MCPS; b). The centre line represents the fitted values from the general additive model with P-spline smooth class, and the shaded region represents the lower and upper bound of the 95% confidence interval of the fitted values. Y-axis is in log2 scale. Only CH driver genes identified in at least 10 individuals are shown here (a, b). c, d, Cumulative frequency of CH individuals by age stratified by gene-specific CH in UKB (c) and MCPS (d). Only CH driver genes identified in at least 10 individuals are shown here. e, Same as Fig. 1b, but with UKB and MCPS age distribution indicated. f, Frequency of CH individuals by age after age- and sex-matching UKB and MCPS participants. Overall CH frequency was 4.55% and 2.87% for UKB and MCPS participants, respectively (P < 2.2 × 10⁻¹⁶). The centre line represents the fitted values from the general additive model with P-spline smooth class, and the shaded region represents the lower and upper bound of the 95% confidence interval of the fitted values (e, f). CH, clonal haematopoiesis; MCPS, Mexico City Prospective Study; UKB, UK Biobank.