Table 1 GWAS summary statistics of leading genetic polymorphisms (smallest P value at each genome-wide significant locus) in the Mexico City Prospective Study

From: Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis

CH

rsID

Gene

Reference allele

Effect allele

MAF

OR [95% Cl]

P value

All CH

rs2853677

TERT

A

G

0.225

1.31 [1.24, 1.37]

1.62 × 10−24

All CH

rs968294563

TCL1B

CT

C

0.012

1.78 [1.49, 2.13]

2.88 × 10−9

DNMT3A

rs2853677

TERT

A

G

0.225

1.40 [1.31, 1.50]

2.83 × 10−21

TET2

rs2736099

TERT

G

A

0.195

1.43 [1.30, 1.56]

2.54 × 10−13

TET2

rs187319135

TCL1B

C

T

0.011

3.59 [2.81, 4.60]

3.70 × 10−18

ASXL1

rs2958593

CSGALNACT1

C

T

0.164

1.63 [1.39, 1.92]

2.37 × 10−8

SF3B1+SRSF2

rs187319135

TCL1B

C

T

0.011

6.92 [4.24, 11.3]

7.34 × 10−10

  1. Test statistics were derived from Firth logistic regression implemented using REGENIE software, adjusted for age, sex and first ten genetic principal components. CH driver genes and GWAS loci are in italics.
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