Extended Data Fig. 6: Comparison of circulating and infiltrating fractions.
From: ImmuneLENS characterizes systemic immune dysregulation in aging and cancer
a, Boxplots showing different fractions calculated in ImmuneLENS in circulating blood and infiltrating tumor samples; pie charts show the percentage of cases when infiltrating fractions is higher or lower than circulating with significance assessed using a two-sided Wilcoxon rank-sum test. P = 0, represents P values less than the limit of double-precision floating numbers in R, 2.22 × 10−308 b, Pearson correlation of infiltrating and circulating fractions within the 100KGP cohort. Dashed black line represents the Pearson correlation = 0 and separates positive and negative correlations. Multiple hypothesis adjustments were performed using the Holm–Bonferroni method. Boxplots in a show the median, lower and upper quartile and with whiskers extending to 1.5× interquartile range above and below the interquartile range. P values for Pearson’s R values were derived from a two-tailed t-distribution using the correlation coefficient and sample size.
