Extended Data Fig. 9: Survival forest plots and circulating T cell fraction and T/B cell ratio interaction.
From: ImmuneLENS characterizes systemic immune dysregulation in aging and cancer
a, Output from CoxPH models showing hazard ratio with 95% confidence intervals for 5-year survival controlled for age, sex, cancer stage and treatment before surgery. Dashed black line represents a hazard ratio of 1. b, Results from a CoxPH model for circulating TCRA T cell fraction and T/B cell ratio together with their interaction term from the 100KGP pan-cancer cohort showing hazard ratio with 95% confidence interval. Dashed black line represents a hazard ratio of 1. c,d, Kaplan–Meier curves for 5-year survival for 100KGP pan-cancer cohort separated into either low- or high-circulating T/B cell ratio or circulating TCRA T cell fraction based on the median values. Multiple hypothesis adjustments were performed using the Benjamini–Hochberg method with individual P values calculated using a two-sided Wald test within the Cox model.
