Fig. 1: Study overview and proteomics workflow.
From: Plasma proteome variation and its genetic determinants in children and adolescents
a, Discovery and replication cohorts used in this study. b, MS-based plasma proteome profiling and SNP-based genotyping were performed on the discovery and replication cohorts. c, Proteome profiling workflow and the computational tools used for processing of proteomics data, including (1) sample organization, (2) sample preparation, (3) data acquisition and (4) informatics. d, Schematic representation of (1 and 2) the association analysis with (3) a quality control step to eliminate artefactual pQTLs as described in the main text and (4) prediction of age, BMI and genotype based on plasma protein levels. ALD, alcohol-related liver disease; m/z, mass to charge ratio; QA, quality assessment; QC, quality control.
