Extended Data Fig. 1: Sex- and obesity-dependent temporal plasma proteome profiles.
From: Plasma proteome variation and its genetic determinants in children and adolescents
a, Hierarchical clustering dendrogram of proteins that are significantly associated with age. The heat maps display z-scored median intensities across age for girls (n = 1,170) and boys (n = 958). b-q, Temporal trajectories of representative proteins stratified by sex and obesity status in Panel (a). Mean values along the age axis and 95% confidence intervals are shown. Obesity status is classified based on BMI-SDS, with ‘yes’ indicating a BMI-SDS ≥ 1.28 (above the 90th percentile) according to Danish reference values, and ‘no’ otherwise. The number of participants in each trajectory group is as follows: males with obesity (n = 538), females with obesity (n = 641), males without obesity (n = 420), and females without obesity (n = 529). MS: mass spectrometry; BMI-SDS: body mass index standard deviation score.
