Extended Data Fig. 2: Disjoint groups analyzed by the non-transmitted estimator and the robust estimator.
From: Family-based genome-wide association study designs for increased power and robustness
The non-transmitted estimator and the robust estimator partition individuals with at least one non-transmitted (NT) parental allele observed into four disjoint groups (Table 1). The ‘Both NT’ group is for individuals with both NT parental alleles observed, such as for sibling pairs in IBD0 and parent-offspring trios. The ‘One NT’ group is for siblings in IBD1 without any genotyped parents, where we have observed one NT parental allele, and it is the maternal or parental allele with equal probability. The ‘Paternal NT’ group is for individuals for whom we have observed the paternal NT allele but not the maternal, for example, genotyped father-child pairs. The ‘Maternal NT’ group is for individuals for whom we have observed the maternal NT allele but not the paternal NT allele, for example, genotyped mother-child pairs.
