Extended Data Fig. 2: Genome-wide evaluation of parameter estimation based on simulations.
From: An enhanced framework for local genetic correlation analysis
HDL-L and LAVA were evaluated for estimating heritability, genetic covariance, and genetic correlation over 50 simulation replicates. Line plots show median mean squared error across 2,468 regions. The heatmap indicates the heritability setting for each phenotype, where \({h}_{1}^{2}\,\) and \({h}_{2}^{2}\) denote the true genome-wide heritability for trait 1 and trait 2, respectively. 10% of SNPs were randomly selected as causal SNPs.
