Extended Data Fig. 6: Supplemental data on DYRK1A and genomic instability. | Nature Genetics

Extended Data Fig. 6: Supplemental data on DYRK1A and genomic instability.

From: Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A

Extended Data Fig. 6

a. Schematic diagram summarising the proposed model whereby DYRK1A overexpression impacts DNA damage response and genomic instability. b. Representative flow cytometry plots showing % of SET2 WT and SET2 DYRK1A KO cells staining positive for γ- H2AX at 8hrs post 3μM etoposide treatment.

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