Enhancer sequences evolve rapidly, which has led to the prevailing view that most are not functionally conserved across species. A study now challenges this assumption by leveraging interspecies point projection — a method that uses genome synteny to uncover hidden enhancer conservation.
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References
Long, H. K., Prescott, S. L. & Wysocka, J. Cell 167, 1170–1187 (2016).
Brawand, D. et al. Nature 478, 343–348 (2011).
Villar, D. et al. Cell 160, 554–566 (2015).
Maeso, I., Irimia, M., Tena, J. J., Casares, F. & Gómez-Skarmeta, J. L. Phil. Trans. R. Soc. Lond. B 368, 20130020 (2013).
Wong, E. S. et al. Science 370, eaax8137 (2020).
Phan, M. H. Q. et al. Nat. Genet. https://doi.org/10.1038/s41588-025-02202-5 (2025).
Bejerano, G. et al. Science 304, 1321–1325 (2004).
Braasch, I. et al. Nat. Genet. 48, 427–437 (2016).
Zhang, X., Kaplow, I. M., Wirthlin, M., Park, T. Y. & Pfenning, A. R. Bioinformatics 36, 4339–4340 (2020).
Harmston, N. et al. Nat. Commun. 8, 441 (2017).
Blow, M. J. et al. Nat. Genet. 42, 806–810 (2010).
Ghandi, M., Lee, D., Mohammad-Noori, M. & Beer, M. A. PLoS Comput. Biol. 10, e1003711 (2014).
Baranasic, D. et al. Nat. Genet. 54, 1037–1050 (2022).
Carroll, S. B. PLoS Biol. 3, e245 (2005).
Irimia, M. et al. Genome Res. 22, 2356–2367 (2012).
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A.d.M. is funded by a European Research Council Starting Grant (950230).
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de Mendoza, A. Genome synteny reveals hidden enhancer conservation. Nat Genet 57, 1328–1329 (2025). https://doi.org/10.1038/s41588-025-02194-2
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DOI: https://doi.org/10.1038/s41588-025-02194-2
