Extended Data Fig. 8: Comparison of ortholog in vivo tested enhancer pairs for their sequence conservation and transcription factor binding site composition.

(a-d) Sequence conservation scores (PhastCons/PhyloP) and direct alignments to human and chicken of tested enhancers at the Tbx20 (a), Pakap (b), Nkx2-5 (c) and Gata4 (d) loci. SVM contribution scores show important sequence features of the 500 bp enhancers in the mouse (top) and chicken (bottom) sequences tested.