Fig. 5: IC heart enhancers from mouse and chicken drive conserved gene expression patterns in vivo. | Nature Genetics

Fig. 5: IC heart enhancers from mouse and chicken drive conserved gene expression patterns in vivo.

From: Conservation of regulatory elements with highly diverged sequences across large evolutionary distances

Fig. 5

a, DC and IC enhancers from mouse (top) and chicken (bottom) drive highly similar expression patterns in the hearts of E10.5 embryos. Individual enhancers show similar tissue-restricted or broad expression patterns. Scale bars, 1,000 µm (embryo), 500 µm (heart). b, Sequence conservation scores (phastCons/PhyloP) and direct alignments to human and chicken of the mouse Hand2-DC and Tbx20-IC enhancers tested in a. SVM contribution (Contr.) scores and TF-MoDISco motif matches show conserved sequence features of the 500-bp enhancer highlighting shared TF motif hits overlapping with seqlets. c, The different order of shared TFBS in IC and DC enhancer pairs is reflected by the computed Kendall tau distance, Kd. d, Kd scores for all functionally conserved DC, IC and NC CRE enhancer pairs. Boxplot shows median and interquartile range. Asterisks indicate the magnitude of the effect size based on Cohen’s d (*d < 0.2, small; **d ≤ 0.5, medium); n, number of enhancer pairs.

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