Fig. 2: CTC cluster clonality is associated with primary tumor clonal complexity and CTC cluster size.
From: Phylogenetic inference reveals clonal heterogeneity in circulating tumor cell clusters
a, Schematic representation of the experimental strategy used to model clonal expansion with varying clonal complexities and infer the prevalence of oligoclonal CTC clusters. Panel a is created with BioRender.com. b, Proportion of oligoclonal CTC clusters disseminated from tumors with low, medium and high clonal complexities (***P < 1 × 10−15, Cochran–Armitage test, Z = 9.89). The total number of interrogated CTC clusters (n) is specified for each primary tumor complexity. c, Proportion of oligoclonality in CTC clusters with two cells and three or more cells (***P = 3.7 × 10−7, Fisher’s exact test (two-sided), odds ratio = 0.33, 95% confidence interval = 0.20–0.52). All mouse samples with detection of CTC clusters in both categories are shown (n = 3 for low, n = 4 for medium and n = 4 for high primary tumor complexities).
