Extended Data Fig. 2: Local gene expression changes in Dac1J/Dac1J limb buds. | Nature Genetics

Extended Data Fig. 2: Local gene expression changes in Dac1J/Dac1J limb buds.

From: Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes

Extended Data Fig. 2

a, Rpkm expression of the 6 genes ate the Lbx1-Fgf8 locus from bulk RNA-sequencing from early E11.5 forelimbs wild type (grey), Dac1J/Dac1J (129s2/Sv) (light green), and Dac1J/Dac1J (C57BL/6) (dark green). Data are shown as mean ± s.e.m. of n = 3 biological replicates. b, In situ hybridization for Fgf8 at E10.5 (left) and in E11.5 (right) wild-type and Dac1J/Dac1J showing whole embryos and forelimbs. Dotted lines draw the shape of the forelimb. AER, apical ectoderm ridge. Scale bars 500um, at least n = 3 embryos were analysed per genotype.

Back to article page