Extended Data Fig. 2: CH characteristics by germline status in the UK Biobank.
From: Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy
a. Heatmap showing the beta coefficients for associations between the number and maximum logVAF of CH mutations and germline genes that significantly increased overall CH-heme or mCA-auto. Shown are the coefficients from linear regression adjusted for age at blood draw, the first three genetic principal components, and exome sequencing batch. *P value < 0.05. Two-sided P value is not corrected for multiple hypothesis testing. b. Comparison of single base substitutions composition (top) and trinucleotide context (middle and bottom) for CH by germline status. Shown are genes/pathways with at least 10 SNVs. NER: Nucleotide Excision Repair, BER: Base excision repair, MMR: mismatch repair.
