Extended Data Fig. 8: Tertiary lymphoid structures are depleted in rNPC, related to Fig. 7. | Nature Genetics

Extended Data Fig. 8: Tertiary lymphoid structures are depleted in rNPC, related to Fig. 7.

From: Single-cell and spatial transcriptomics reveal mechanisms of radioresistance and immune escape in recurrent nasopharyngeal carcinoma

Extended Data Fig. 8

(a-b) Violin plots showing the percentages of various immune-cell types in TLS (green) and other tissues (orange) in two representative patients. Two-sided Wilcoxon rank-sum test. (c-d) Violin plots showing the percentages of B, CD4+ T, and CD8+ T cell subclusters in TLS (green) and other tissues (orange) in two representative patients. Two-sided Wilcoxon rank-sum test. (e-f) Kaplan-Meier analysis showing the PFS of patients from validation cohort 4, stratified by low (green) or high (blue) expression of MS4A1 (n) and BANK1 (o). Two-sided log-rank test. (g) Kaplan-Meier analysis showing the PFS of patients from validation cohort 4, stratified by low (green) or high (blue) ratio of B cells. Two-sided log-rank test.

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