Table 4 MVMR analysis of All-PA–leisure setting BMI as exposures

From: A contextual genomic perspective on physical activity and its relationship to health, well being and illness

Exposure

Outcome

n

β (s.e.)

P value

PA

Aneurysm (abdominal aortic)

19

−0.087 (0.055)

0.11

BMI

Aneurysm (abdominal aortic)

112

0.31 (0.18)

0.092

PA

COVID-19 hospitalization

19

−0.067 (0.016)

2.8×10−5

BMI

COVID-19 hospitalization

113

0.37 (0.05)

8.2 × 10−13

PA

asthma

19

−0.0069 (0.0026)

6.7 × 10−3

BMI

asthma

113

−0.0035 (0.0086)

0.69

PA

HDL-C

19

0.0221 (0.0047)

2.3×10−6

BMI

HDL-C

113

−0.042 (0.016)

7.0 × 10−3

PA

Triglycerides

19

−0.038 (0.011)

3.6×10−4

BMI

Triglycerides

113

0.040 (0.035)

0.26

PA

Type 2 diabetes

16

−0.058 (0.057)

0.30

BMI

Type 2 diabetes

101

0.42 (0.18)

0.19

PA

Parental survival

18

0.030 (0.010)

2.9×10−3

BMI

Parental survival

109

−0.171 (0.034)

4.4 × 10−7

PA

Phenotypic age acceleration

19

−0.091 (0.044)

3.7 × 10−2

BMI

Phenotypic age acceleration

113

0.92 (0.15)

4.8 × 10−10

PA

Osteoarthritis

19

−0.0037 (0.0012)

1.4×10−3

BMI

Osteoarthritis

113

0.0253 (0.0039)

1.3 × 10−10

PA

Gastroesophageal reflux disease

19

−0.063 (0.015)

2.3×10−5

BMI

Gastroesophageal reflux disease

113

0.141 (0.050)

4.6 × 10−3

  1. For the instrumental variables, we used a threshold P = 10−5. Significant results after multiple testing correction (P < 5.0 × 10−3 outcomes) are highlighted in bold. Tests were two-sided.