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Human development

Advancing the spatiotemporal atlas of the developing human heart

Nature Genetics volume 57, pages 2623–2625 (2025)Cite this article

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Spatial transcriptomics enables the characterization of diverse cell types with increasing resolution while retaining the spatial context of complex tissues. A study combines single-cell and spatial ‘spot’-based transcriptome measurements to identify cell states in the developing human heart and define spatial relationships within cardiac niches.

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Fig. 1: Generating a spatiotemporal map of the developing human heart.

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Acknowledgements

L.K.I.-S. is supported by an AHA postdoctoral fellowship (25POST1376966). B.G.B. is a recipient of awards from the National Institutes of Health (UM1HL098179, R01HL114948), Additional Ventures, and the Younger Family Fund.

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Authors and Affiliations

  1. Gladstone Institutes, San Francisco, CA, USA

    Lisa K. Iwamoto-Stohl & Benoit G. Bruneau

  2. Roddenberry Center for Stem Cell Biology and Medicine, Gladstone Institutes, San Francisco, CA, USA

    Benoit G. Bruneau

  3. Department of Pediatrics, University of California, San Francisco, CA, USA

    Benoit G. Bruneau

  4. Cardiovascular Research Institute, University of California, San Francisco, CA, USA

    Benoit G. Bruneau

  5. Institute for Human Genetics, University of California, San Francisco, CA, USA

    Benoit G. Bruneau

  6. Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA, USA

    Benoit G. Bruneau

Authors
  1. Lisa K. Iwamoto-Stohl
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  2. Benoit G. Bruneau
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Corresponding author

Correspondence to Benoit G. Bruneau.

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Competing interests

B.G.B. is a founder, shareholder, and advisor of Tenaya Therapeutics and an advisor for Silver Creek Pharmaceuticals. The work presented here is not related to the interests of these commercial entities.

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Iwamoto-Stohl, L.K., Bruneau, B.G. Advancing the spatiotemporal atlas of the developing human heart. Nat Genet 57, 2623–2625 (2025). https://doi.org/10.1038/s41588-025-02261-8

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