Extended Data Fig. 4: Cell-type level hypo-methylated regions are enriched for specific transcription factor (TF) binding motifs.
From: Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue
We show the top five cell-type level TF binding motifs (sorted by P) that are enriched among the hypo-methylated regions of the SAT cell-types. Statistical significance was determined using HOMER (binomial test) on each cell-type separately (see Methods). False positive rate was calibrated by a stringent cutoff on the unadjusted P values (that is, P < 1×10−12). ASPC, adipose stem and progenitor cell.
