Extended Data Fig. 8: Browser-based stacked views of multimodal data for adipocyte marker genes in five major SAT cell-types.
From: Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue
a-b, From top to bottom: chromatin conformation contact heatmap, imputed at a 10-kb resolution and colored at log-normalized scale; boundary probabilities calculated at a 25-kb resolution; and chromosome compartment scores evaluated at a 100-kb resolution, where the A compartments are colored red and the B compartments blue. The shaded trapezoid connects the top panels to a zoomed-in view of the CG methylation patterns surrounding the gene body, extending 5-kb up- and downstream. Vertical dashed lines mark the gene start and end positions. Black dots represent the detected chromatin loop summits. The black dashed triangles in the contact heatmap highlight differential domains that are present only in adipocytes: one encapsulates the ADIPOQ gene (a), and two reside within the TENM3 gene body (b). SAT, subcutaneous adipose tissue; and ASPC, adipose stem and progenitor cell.
