Extended Data Fig. 10: Abdominal obesity -associated variants are enriched for the adipocyte A compartment.
From: Single-cell DNA methylome and 3D genome atlas of human subcutaneous adipose tissue
a, The clumped and thresholded variants (R2 < 0.2, unadjusted P < 0.05) used for constructing the adipocyte compartment PRSs for abdominal obesity (employing WHRadjBMI as a proxy) are plotted by genomic position against the unadjusted -log10P from the UK Biobank WHRadjBMI GWAS (n = 195,863 unrelated Europeans). SNPs landing in the adipocyte A compartments are colored red, while SNPs landing in the adipocyte B compartments are colored blue. The horizontal dashed line indicates genome-wide significance (unadjusted P < 5 × 10−8). b, Bar plot showing the number of WHRadjBMI-associated variants in (a), stratified by the adipocyte compartment assignment. c, Similar to (b) except showing the number of independent (R2 < 0.2) WHRadjBMI GWAS variants, passing genome-wide significance (unadjusted P < 5 × 10−8). PRS, polygenic risk score; WHRadjBMI, waist-hip-ratio adjusted for body mass index; and SNP, single nucleotide polymorphism.
