Extended Data Fig. 3: Convergent DNA methylation and genomic alterations in drivers.
From: DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution
a) Impact of SCNA loss status on gene expression for genomic TSGs (left) and oncogenes (right) for LUAD and LUSC separately. Negative values indicate decreased expression in tumors where the gene is lost by SCNA, positive values indicate increased expression in tumors where the gene is lost by SCNA, P < 0.05 (*) (t-test). b) Number of tumors with alterations based on SCNA loss (blue) or promoter hypermethylation (yellow) in genomic oncogenes. Parallel events, defined as hypermethylation and copy number loss occurring in different regions of the same tumor (red). Double hit events, defined as tumors exhibiting promoter hypermethylation and somatic copy number loss in the same region (green); other combinations of events, such as somatic copy number gains, mutations or promoter hypomethylation events and combinations thereof (white). Pie chart, summarising the percentage of each event for all genomic oncogenes.
