Extended Data Fig. 5: PIK3CA mutation frequencies in de novo UC by body mass.

Bar plots of TCGA (left) and CPTAC (right) de novo UC cohorts; bars represent PIK3CA mutation frequencies across three body mass index (BMI) groups: normal weight (NW, BMI < 25), overweight (OW, BMI 25 – 29.9), and obese (OB, BMI ≥ 30). Error bars reflect standard deviation from the β-distribution; significance analysis by two-sided Fisher’s exact test; numbers in bars indicate mutated tumor count per group.