Extended Data Fig. 6: Comparison of meta-analysis and EUR summary statistics.

a, As in Fig. 3c, the P-value in EUR is plotted compared to the P-value in the meta-analysis, as a density plot to indicate the relative number of points in each region of the plot. Three quadrants are highlighted for significant in meta-analysis only (green), both meta-analysis and EUR (purple), and EUR-only (blue). b, Summaries and meta-data of the variants in each of these three quadrants are shown. Heterogeneous is defined as Cochran’s Q P < 0.01, low INFO score is defined as INFO < 0.9, and low quality is defined as failing quality filters from gnomAD or allele frequency significantly differing between gnomAD and Pan-UKB in at least one ancestry group (see Supplementary Note, QC of summary statistics). Common is defined as frequency > 1%.