Extended Data Fig. 8: Cell cycle dynamics regulated by TFs and their doses, related to Fig. 6. | Nature Genetics

Extended Data Fig. 8: Cell cycle dynamics regulated by TFs and their doses, related to Fig. 6.

From: Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq

Extended Data Fig. 8

a-d, 2D density contour plots of S and G2/M scores showing cell cycle dynamics of confluent (a, left) and non-confluent control (a, right), T (b), E2F2 (c), and MYCN (d) cells. See Supplementary Note 7. The colors of contour lines represent the probability associated with the computed highest density region. For example, 50% represents the region capturing 50% of the data points. P, adjusted P value. e, Bar plots showing the fraction of cells in each adjusted cell cycle phase across binned doses of Runx2 or Pax9. See Supplementary Table 5 and Methods for statistics and exact P values.

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