Extended Data Fig. 8: Frequency distribution of neoantigens.
From: Epigenetically driven and early immune evasion in colorectal cancer evolution
(a–c) Cumulative number of non-antigenic (grey) and neoantigen (red) mutations shown against the inverse of the variant allele frequency. All mutations were pulled together from fresh frozen whole genome sequencing (FF-WGS) non-escaped cancers (a), formalin-fixed paraffin-embedded panel sequencing (FFPE-PS) superficial tumour samples (b), or FF-WGS escaped MMRp samples (c). (d–f) The cumulative distribution of the number of mutations shared by a given number of biopsies, shown for non-neoantigen (in grey) and neoantigen (in red) mutations in the indicated cancers. Two-sided Kolmogorov-Smirnov test results are shown above the graphs.
