Fig. 1: Genome-wide multi-ancestry gene-burden test for T2D and BMI in UKBB. | Nature Genetics

Fig. 1: Genome-wide multi-ancestry gene-burden test for T2D and BMI in UKBB.

From: Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health

Fig. 1: Genome-wide multi-ancestry gene-burden test for T2D and BMI in UKBB.

a,b, Manhattan plots showing gene-burden test results for T2D (a) and BMI (b) with unadjusted two-sided P values derived from gene-burden testing conducted in BOLT-LMM and plotted on a −log10 scale. Genes passing exome-wide significance (P < 6.15 × 10−7 (0.05/81,350)) are labeled. Points are annotated with variant mask information. MISS–REVEL, missense variants with REVEL scores above 0.5 or 0.7; HC–PTV, high-confidence PTVs.

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