Fig. 2: Discovery and replication of significant associations with BMI and T2D in UKBB and AoU. | Nature Genetics

Fig. 2: Discovery and replication of significant associations with BMI and T2D in UKBB and AoU.

From: Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health

Fig. 2: Discovery and replication of significant associations with BMI and T2D in UKBB and AoU.

Plots show effect estimates for predicted damaging mutations in the indicated gene on BMI (left) and T2D risk (right) in the UKBB and AoU. In UKBB, effect estimates for BMI were derived using GLMs. In AoU, effect estimates were approximated from score statistics and their variances under a GLM framework. nBMI, UKBB = 481,137; nBMI, AoU = 219,015; nT2D, UKBB = 489,941; nT2D, AoU = 219,015. Odds of T2D are plotted on a log10 scale. All error bars represent 95% CIs and all P values are two-sided. Gene names of results replicated in AoU are highlighted in bold.

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