Fig. 3: PheWAS of BMI and T2D associated genes in UKBB.
a,b, Effects of the most significant Gene × Mask association with BMI (a) or T2D (b) were assessed (Methods) on a panel of 79 traits, and resulting P values were plotted on a −log10 scale. P values are two-sided and unadjusted. Test statistics were derived from linear and logistic regression models performed using the GLM framework. Numbers of participants are provided in Supplementary Tables 10 and 11. Points are colored according to classification of phenotype; the orientations of triangles indicate the direction of effect for significant traits. For clarity, only a subset of traits and the most significant Gene × Mask association (for genes with more than one mask significantly associated with T2D or BMI) are displayed. UBR3, which was associated with both T2D and BMI in our discovery analysis, is presented alongside BMI risk genes only to avoid duplication. The solid horizontal lines represent a Bonferroni-corrected threshold for statistical significance of 2.35 × 10−5 (0.05/2,132 Phenotype × Mask associations).
