Fig. 4: Loss-of-function variants in IRS2 increase CKD risk. | Nature Genetics

Fig. 4: Loss-of-function variants in IRS2 increase CKD risk.

From: Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health

Fig. 4: Loss-of-function variants in IRS2 increase CKD risk.

a, Effects of protein truncating variants in IRS2 on various measures of eGFR (ml min−1 1.73m−2) and CKD (OR) are plotted with 95% CIs. All P values are two-sided and unadjusted. The presented summary statistics are derived from linear (eGFR) and logistic regression (CKD risk) implemented in the GLM framework. b, Effects of rare predicted damaging mutations in the labeled genes on T2D risk are plotted (log(OR) T2D risk ± 95% CIs) against the effect on eGFR (beta estimate ± 95% CIs) across three different methods of estimation to illustrate that the effect of PTVs in IRS2 on renal function seem independent of its effect on T2D. For clarity, only the Gene × Mask combination most significantly associated with T2D is plotted. All error bars represent 95% CIs. Plotted test statistics are derived from linear regression for eGFR and from logistic regression for T2D implemented using GLMs. nCKD, T2D = 489,941; nCreatinine eGFR = 461,884; nCystatin-C eGFR = 462,081; nCystatin-C Creatinine eGFR = 461,543.

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