Fig. 5: Genetic evidence for functional heterogeneity of insulin receptor substrates in humans. | Nature Genetics

Fig. 5: Genetic evidence for functional heterogeneity of insulin receptor substrates in humans.

From: Population-scale gene-based analysis of whole-genome sequencing provides insights into metabolic health

Fig. 5: Genetic evidence for functional heterogeneity of insulin receptor substrates in humans.

Effects of PTVs in IRS1 and IRS2 on continuous traits are beta-estimates from linear regression plotted in centimeters for height and kilograms for fat-free mass, and as OR from logistic regression for T2D. Odds of T2D are plotted on a log scale. All error bars represent 95% CIs. nFat Free Mass = 481,100; nHeight = 488,455; nT2D = 489,941.

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