Fig. 7: Model of HNF4G and FOXA1 in primary tumor and metastatic context.
From: Transcription factor switching drives subtype-specific pancreatic cancer
The top scenario represents primary tumor contexts, where HNF4G is the dominant transcription factor, required for chromatin accessibility, gene expression and cell growth. The bottom scenario represents metastatic contexts, where FOXA1 becomes functional and the role of HNF4G is diminished. The switch from HNF4G dependency to FOXA1 dependency mediates the molecular transition from primary tumor growth to metastasis.
