Fig. 1: Overview of REMETA workflow. | Nature Genetics

Fig. 1: Overview of REMETA workflow.

From: Computationally efficient meta-analysis of gene-based tests using summary statistics in large-scale genetic studies

Fig. 1: Overview of REMETA workflow.The alternative text for this image may have been generated using AI.

The REMETA workflow has three steps: (1) LD matrix construction in REMETA, (2) single-variant association testing with REGENIE and (3) meta-analysis. REMETA uses gene sets, variant annotations and an optional allele frequency file to construct gene-based tests from single-variant summary statistics and LD matrices during meta-analysis. P values across masks and tests are combined using ACAT into a single ‘GENE_P’ P value per gene to limit multiple testing. The GENE_P definition file defines which masks to include in GENE_P.

Back to article page