Fig. 2: MDD subtype GWAS meta-analysis in the Nordic cohorts and SNP heritability. | Nature Genetics

Fig. 2: MDD subtype GWAS meta-analysis in the Nordic cohorts and SNP heritability.

From: Genome-wide association analyses identify distinct genetic architectures for early-onset and late-onset depression

Fig. 2: MDD subtype GWAS meta-analysis in the Nordic cohorts and SNP heritability.

a,b, Mirrored Manhattan plots of the GWAS results from the combined Nordic countries, using inverse-variance-weighted meta-analysis with a genome-wide significance threshold of P < 5 × 10−8 (denoted by the dashed horizontal line), for eoMDD (a) and loMDD (b). c, Enrichment of open chromatin marks in the eoMDD and loMDD GWAS. The dashed line indicates the one-sided Bonferroni-corrected P threshold, set at P = 0.05/102 = 0.0005. d, Single-nucleotide polymorphism (SNP)-based heritability \(\left({h}_{{\rm{SNP}}}^{2}\right)\) across a range of population prevalence estimates, with the labeled dashed lines indicating the point estimate of the population prevalence. e, Genetic overlap between broad MDD, eoMDD and loMDD, with the upper triangle containing the standard errors and the diagonal containing estimates of polygenicity from SBayesS. * For loMDD, the algorithm did not converge, making the polygenicity estimate unreliable, although it was consistently higher than for eoMDD across successful runs.

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