Fig. 1: Hypothyroidism lead variants and their associations with thyroid hormones.
From: Genome-wide association study and polygenic risk prediction of hypothyroidism
a, Relationships between minor allele frequencies and ORs for the 350 lead variants that were identified in the hypothyroidism genome-wide meta-analysis (113,393 cases and 1,065,268 controls) or through an endophenotype-driven analysis using thyroid-stimulating hormone genome-wide associations as priors. Coding variants are squared, new associations are turquoise, and known associations are gray. b, Relationships between hypothyroidism risk and changes in thyroid-stimulating hormone for 349 of 350 lead variants. c, Relation between hypothyroidism risk and change in free thyroxine for 348 of 350 lead variants. In b and c, the centerline represents the linear regression, and the shaded error band shows the 95% CI around the regression line. Statistical associations were assessed using two-sided Pearson correlation tests. No multiple testing correction was applied for these correlation analyses.
