Fig. 2: PRS association with and prediction of hypothyroidism.
From: Genome-wide association study and polygenic risk prediction of hypothyroidism
a, Associations between 10 deciles of the PRS and risk of hypothyroidism are presented as OR point estimates ± 95% CI error bars, estimated using logistic regression models adjusted for age, sex and PCs. No adjustments were made for multiple comparisons. b, Prediction of incident hypothyroidism cases. The benchmark model consisted of age, sex and four PCs. Prevalent risk factors for hypothyroidism were added iteratively to the benchmark model. The center of each error bar represents the AUC, and error bars indicate the 95% CIs, displayed in absolute terms on the right. No adjustments were made for multiple comparisons. MS, multiple sclerosis; PMR, polymyalgia rheumatica; PsA, psoriatic arthritis; RA, rheumatoid arthritis; DS, Down syndrome; SSc, systemic sclerosis; SLE, systemic lupus erythematosus; Celiac, celiac disease; Sjögren, Sjögren’s disease; T1D, type 1 diabetes.
