Fig. 3: Progression from SCH to overt disease.
From: Genome-wide association study and polygenic risk prediction of hypothyroidism
Ten-year cumulative incidence of disease progression from SCH to overt hypothyroidism in 8,114 primary care patients from the UKB. Lines represent the cumulative incidence, and shaded bands indicate the 95% CI. The green line represents individuals with low polygenic risk (<10th percentile), yellow represents intermediate polygenic risk (10th–90th percentile), and red represents high polygenic risk (>90th percentile). Cumulative incidence was estimated using the Aalen-Johansen estimator, which accounts for the competing risk of death. HRs with 95% CIs were estimated using two-sided Cox proportional hazards models, adjusted for age, sex and four PCs. No adjustments were made for multiple comparisons.
