Fig. 4: Stratifying hypothyroidism risk using lifestyle characteristics and polygenic risk in the UKB.
From: Genome-wide association study and polygenic risk prediction of hypothyroidism
a, Risk for incident hypothyroidism according to different lifestyle characteristics and categories. Data are presented as HR point estimates ±95% CIs, derived from two-sided Cox proportional hazards models, adjusted for age, sex and PCs. The center of each error bar represents the mean HR estimate. b,c, Ten-year risk of hypothyroidism, stratified by sex (b, females; c, males), age group, obesity status (BMI > 30), exercise regularity (yes/no), smoking status (yes/no) and divisions within the PRS across ten deciles (Q1–10).
