Fig. 5: Phenome-wide associations between the hypothyroidism PRS and cancer and cardiometabolic phenotypes in the UKB.
From: Genome-wide association study and polygenic risk prediction of hypothyroidism
The figure shows associations between the hypothyroidism PRS and 50 binary disease outcomes. OR reflect the change in disease risk per 1 s.d. increase in the PRS, estimated using logistic regression models adjusted for age, sex and four PCs. P-values were calculated using two-sided Wald tests. Each colored triangle indicates a significant association after Bonferroni correction (P < 0.001, that is, 0.05/50). Upward-pointing triangles indicate increased risk and downward-pointing triangles indicate decreased risk.
