Extended Data Fig. 8: Additional CNA profiles. | Nature Genetics

Extended Data Fig. 8: Additional CNA profiles.

From: Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models

Extended Data Fig. 8

a, b, Cumulative CNA plots of human entities which are used for comparison to mouse tumors. c–e, CNA profiles of three individual mice per mouse model indicated. Recurrent changes are color coded. Middle sections of panels display the frequency of the color-coded CNAs in all analyzed mice of that model as well as the respective syntenic regions on the human genome. Lower sections show the average human CNA profile of the indicated human individual mice of the indicated models. Overlapping changes between mice and human in the same direction are depicted in red. f, T-SNE analysis of all human RTK-driven HGGs shown in Extended Data Fig. 8b, e. chr. – chromosome, CNA - copy number aberration, CPC - choroid plexus carcinoma.

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