Most aggressive metastatic prostate cancers are driven by activity of the androgen receptor (AR). This steroid-responsive transcription factor has a complex series of regulatory interactions with ligands, proteins and DNA that are required for normal biology and cancer phenotypes. We performed experiments to systematically identify genes required for maintaining AR protein levels, revealing mechanisms of regulating AR activity in the nucleus.
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References
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This is a summary of: Li, H. et al. Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer. Nat. Genet. https://doi.org/10.1038/s41588-025-02388-8 (2025).
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Regulators of androgen receptor activity revealed by CRISPR interference screens. Nat Genet 57, 2952–2953 (2025). https://doi.org/10.1038/s41588-025-02432-7
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DOI: https://doi.org/10.1038/s41588-025-02432-7
